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Resource: Nothing is Not Connected to the Brain: Talks with The First Functional Neurologist


As a neurologist applying the concepts of Functional Medicine to help each patient re-establish healthy communications between his/her brain, gut, and immune system, David Perlmutter, MD has long worked to disprove the notion that the brain lacks regenerative capacity. In his podcast The Empowering Neurologist, he takes a specialized look at how lifestyle can add to or subtract from health over time, and the difference made by better-informed choices. His guests include well-known clinicians like Terry Wahls, MD, Mark Hyman, MD, and his colleague Dale Bredesen, MD, and with an enduring interest in groundbreaking science, he has also interviewed researchers like metabolic detoxification expert Deanna Minich, PhD and his own mentor, the Father of Functional Medicine Dr. Jeffrey Bland.


Here are links to a few of Dr. Perlmutter’s recent interviews:

  • How can ‘nourishing’ and ‘starving’ be very strategically combined to activate rejuvenating stem cells while clearing out dysfunctional cells and restoring healthier immune balance? What is the magic amount of exercise for triggering some of the same biochemical benefits as fasting? What does cellular aging have to teach us about getting rid of belly fat? In this talk, Valter Longo, PhD explains how the Fasting-Mimicking Diet came into being and how profoundly it contrasts to modern lifestyles of ‘starving in the face of overnutrition.’

  • Why should we try to reconnect to the prefrontal cortex (with its relationship to more feminine behaviors) and away from fear, the cortisol response, and the amygdala, as modern life often seems to encourage? With gynecologist and biohacker Sara Gottfried, MD, Dr. Perlmutter discusses how male and female brains specialize and are activated in different ways, how this map into different health conditions—especially during aging—and how we can take advantage of that to produce health in an individualized way.

  • What do ketones do to the brain, especially during stress and biological aging? In this deep dive, fellow ketogenic diet proponent Dominic D’Agostino, PhD describes how ketones carry epigenetic, anti-inflammatory, and anti-excitotoxic messages that go beyond their benefits as clean and even antioxidant energy sources for mitochondria, particularly in the brain. Ketones are a normal body metabolite during fasting, yet have been discovered to be extremely efficient at addressing certain types of brain dysfunction, with implications in health issues ranging from cancer and Lou Gehrig’s disease to stress endurance and physical performance.

  • How was a computer scientist able to confirm that the rapid growth in autistic disorders is related to environmental factors, gut issues, and micronutrient deficiencies—and not primarily a genetic problem? What essential nutrients does glyphosate chelate? MIT’s Stephanie Seneff, PhD talks with Dr. Perlmutter about food contamination with glyphosate and the impacts of widely-used toxics on human (not to mention soil!) microbiomes, metabolic detoxification, methylation function, and other issues linked to autism. It turns out that humans (and our folate production) are not, after all, immune from these substances’ effects on microbes. Don’t miss the graph mapping glyphosate application to corn and soy with numbers of children being treated for autism.

  • Find out what kindness has to do with clean arteries, the curious relationship between the microbiome and breast health, the seasonal message of glucose in ripe fruits, and how andropause and menopause are more like beginnings than endings in this talk with board-certified ob/gyn Christiane Northrup, MD, whom Dr. Perlmutter has known and learned from for decades and is the author of one of the most important books he has ever read: Goddesses Never Age.

  • “In holistic medicine, there are no specialties.” From this eye-opening discussion with board-certified holistic psychiatrist Kelly Brogan, MD (author of A Mind of Your Own), we learn the web view of what depression really is, question the “serotonin theory” and perceived necessity of medication, hear evidence from unpublished negative studies, relearn how to listen to the body’s urgent and insistent messaging, and consider the central importance of the gut in brain, mood, blood sugar level, and immune balance as well as the disconnect among human evolution, modern chemical usage, and unremitting inflammatory response. Bringing Functional Medicine to psychiatry, Drs. Perlmutter and Brogan agree on dietary adjustment as the single most powerful intervention, able to address more aspects of pathology simultaneously than any other treatment.


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